Autoantibodies are antibodies (immune proteins) that mistakenly target and react with a person's own tissues or organs. One or more autoantibodies may be produced by a person's immune system when it fails to distinguish between "self" and "non-self." Usually the immune system is able to discriminate between foreign substances ("non-self") and the body’s own cells ("self"). It produces antibodies only when it perceives that it has been exposed to a threat ("non-self"), such as bacteria or viruses. However, when the immune system ceases to recognize one or more of the body's normal constituents as "self," it may produce autoantibodies that react with its own cells, tissues, and/or organs. This may cause inflammation, damage, and/or dysfunction of organs or systems, leading to signs and symptoms of autoimmune disorders.
Some autoantibodies do not cause tissue injury directly but are thought to be part of an overall immune response that can cause inflammation and damage. Their presence in the blood can indicate that an autoimmune process is ongoing. Examples include antibodies related to celiac disease and type 1 diabetes
The list below includes some of the autoantibody tests that are used to identify systemic autoimmune disorders. These disorders may cause signs and symptoms associated with inflammation throughout the body.
Antinuclear Antibodies (ANA Antineutrophil Cytoplasmic Antibodies (ANCA) Anti-Double Stranded DNA (anti-dsDNA) Anticentromere Antibodies (ACA) Antihistone Antibodies Cyclic Citrullinated Peptide Antibodies (CCP) Extractable Nuclear Antigen Antibodies Rheumatoid Factor (RF)
Organ-specific autoantibodiesThese are examples of autoantibodies associated with certain systems or
Cardiolipin Antibodies Beta-2 Glycoprotein 1 Antibodies Antiphospholipid Antibodies (APA) Lupus anticoagulants (LA)
Anti-Tissue Transglutaminase (anti-tTG) and Anti-Gliadin Antibodies (AGA) Intrinsic Factor Antibodies Parietal Cell Antibodies
Smooth Muscle Antibodies (SMA) Antimitochondrial Antibodies (AMA) Liver Kidney Microsome Type 1 Antibodies (anti-LKM-1)
Anti-Glomerular Basement Membrane (GBM) Muscles Acetylcholine Receptor (AChR) Antibodies.